BFS - Blow Fill & Seal machines

8 Machines

Blow fill & seal machines, abbreviated as BFS, are advanced automated systems that integrate the forming, filling and sealing of plastic containers into a single continuous operation in a sterile environment, ensuring the aseptic production of liquid pharmaceutical products. Makinate offers a wide selection of used blow fill & seal machines from leading manufacturers such as Rommelag, Weiler, Krones and other specialized brands, providing reliable solutions for aseptic packaging in the pharmaceutical, ophthalmic and medical sectors.

Blow fill & seal technology for aseptic packaging

BFS (Blow Fill & Seal) technology is mainly used in the pharmaceutical industry and consists of producing plastic containers and filling them with a liquid product in a single automated operation.... This is a primary packaging process generally carried out in a sterile environment, ensuring the highest standards of safety and purity for sensitive products intended for medical use.

Products packaged with BFS technology

Products packaged using blow fill & seal machines are typically ophthalmic eye drops, injectable solutions, dialysis solutions, as well as drainage and irrigation solutions. These products must therefore be completely free of any contaminating particles, making BFS technology ideal for guaranteeing absolute sterility throughout the entire packaging process.

Forming, filling and sealing process

The blow fill & seal process follows a precise and fully automated sequence. Pharmaceutical-grade plastic resin is extruded vertically to form a continuous tube called a parison. The extruded tube is then enclosed in a closed mold, blown to give it the desired container shape, filled with sterile liquid product and finally sealed hermetically. The mold generally contains multiple cavities, allowing the simultaneous production of multiple containers to increase production efficiency.

Advantages of blow fill & seal machines

Blow fill & seal machines offer numerous advantages compared to traditional packaging methods:

Guaranteed sterility: a fully automated process in a controlled environment that eliminates the risk of human contamination
Production efficiency: forming, filling and sealing in a single continuous operation with high output capacity
Safe containers: unbreakable, lightweight plastic ampoules with no risk of shards compared to glass

Applications in the pharmaceutical sector

Blow fill & seal machines are mainly used in the pharmaceutical sector for the production of sterile ophthalmic solutions, single-dose injectable products, respiratory solutions, dialysis products and other liquid formulations that require aseptic packaging. BFS technology is particularly appreciated for the production of small unit volumes, from 0.1 ml up to larger formats, ensuring precise dosing and patient safety.

Blow fill & seal technology for aseptic packaging

Products packaged with BFS technology

Forming, filling and sealing process

Advantages of blow fill & seal machines

Blow fill & seal machines offer numerous advantages compared to traditional packaging methods:

Guaranteed sterility: a fully automated process in a controlled environment that eliminates the risk of human contamination
Production efficiency: forming, filling and sealing in a single continuous operation with high output capacity
Safe containers: unbreakable, lightweight plastic ampoules with no risk of shards compared to glass